Hydrochloric Acid → 3,5-Diamino-4-hydroxybenzoic acid dihydrochloride

HRID 439316Notes

Reaction equation

HRID 439316 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([NH2:12])[C:10]=1[OH:11])[C:5]([OH:7])=[O:6].[ClH:13]>>[ClH:13].[ClH:13].[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([NH2:12])[C:10]=1[OH:11])[C:5]([OH:7])=[O:6]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 133101HCID 133101, compound

Product 1

HCID 1331003,5-Diamino-4-hydroxybenzoic acid dihydrochlorideYield 90%

Procedure

3,5-Diamino-4-hydroxybenzoic acid (2 g, 11.9 mmole) was dissolved in 6N hydrochloric acid (50 ml) and refluxed for 2 hours. The mixture was evaporated to dryness and the residue was treated with ethyl acetate (50 ml), filtered and dried to give 3,5-diamino-4-hydroxybenzoic acid dihydrochloride (2.58 g, 90%), m.p. 260°-262° C. (dec.) (lit. ref., Chemical Abstracts, 1908, 2379, m.p. 260° C. (dec)).

Workup

  1. temperaturerefluxed for 2 hours
  2. customThe mixture was evaporated to dryness
  3. additionthe residue was treated with ethyl acetate (50 ml)
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-062adf94a77b4aec92be6e88e155f82a
Source dataset
uspto-grants-1996_05
Patent number
US05514676

Reaction notes

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