Benzenesulfonyl chloride → HCID 10784030, compound

HRID 439393Notes

Reaction equation

HRID 439393 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[C:3]=1[C:11]([O:13][CH3:14])=[O:12].[C:15]1([S:21](Cl)(=[O:23])=[O:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH3:14][O:13][C:11]([C:3]1[C:4]([C:7]([F:10])([F:9])[F:8])=[N:5][O:6][C:2]=1[NH:1][S:21]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:23])=[O:22])=[O:12]

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 10584549HCID 10584549, compound

Product 1

HCID 10784030HCID 10784030, compoundYield 85%

Procedure

N-(4-Methoxycarbonyl-3-trifluoromethyl-5-isoxazolyl)benzenesulfonamide was prepared as described in Example 25 from 5-amino-4-methoxycarbonyl-3-trifluoromethylisoxazole and benzenesulfonyl chloride in 85% yield. The crude product was purified by recrystallization from methanol/water to give a solid, m.p. 100°-101° C.

Workup

  1. customThe crude product was purified by recrystallization from methanol/water
  2. customto give a solid, m.p. 100°-101° C.

Sources & evidence

ORD record
ord-31154794d8d3437389e6f76553e40f99
Source dataset
uspto-grants-1996_05
Patent number
US05514691

Reaction notes

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