反应详情

温度

50 °C

2.34 Grams (17.5 mmol) of the N-chlorosuccinimide was added to a solution consisting of 3.26 g (16 mmol) of the 2-phenyl-4,5-bis(hydroxymethyl) imidazole, 24 ml of methoxyethanol and 37 ml of dioxane maintained at a temperature of 50° C. with stirring. The mixture was then reacted at the same temperature for 24 hours with stirring, and the reaction solution was concentrated under reduced pressure. The obtained reaction product was washed with water and was recrystallized from propyl alcohol to obtain a 2-phenyl-4-chloro-5-(hydroxymethyl) imidazole in an amount of 1.0 g (yield 30%).

1. customThe mixture was then reacted at the same temperature for 24 hours
2. stirringwith stirring
3. concentrationthe reaction solution was concentrated under reduced pressure
4. customThe obtained reaction product
5. washwas washed with water
6. customwas recrystallized from propyl alcohol