Thionyl Chloride → Benzene, 1-(chloromethyl)-4-(phenylmethyl)-

HRID 439775Notes

Reaction equation

HRID 439775 reaction equation
[CH2:1]([C:8]1[CH:15]=[CH:14][C:11]([CH2:12]O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:18])=O>C(Cl)(Cl)Cl>[CH2:1]([C:8]1[CH:15]=[CH:14][C:11]([CH2:12][Cl:18])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 5976144-(Phenylmethyl)benzenemethanol

Product 1

HCID 84334Benzene, 1-(chloromethyl)-4-(phenylmethyl)-

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
0 °C

Procedure

4-benzylbenzyl alcohol (181.47 g) was dissolved into chloroform (100 ml), and thionyl chloride (66.8 ml) was added with stirring at a 0° C. After stirring at 0° C. for 4 hours, reaction mixture was concentrated under reduced pressure to give the title compound (198.34 g). This product was used in the subsequent procedure without purification.

Workup

  1. additionwas added
  2. stirringAfter stirring at 0° C. for 4 hours
  3. customreaction mixture
  4. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-398b48610b59430bad1b318ae6ff4a76
Source dataset
uspto-grants-1996_05
Patent number
US05516777

Reaction notes

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