反应详情

A mixture of 3-(4-benzylphenyl)-6-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine 1.35 g), sodium hydroxide (1.50 g), ethanol (35 ml) and water (35 ml) was stirred under heating reflux for 2 hours. Then, to the reaction mixture was added water (50 ml), and hydrochloric acid was added at 0° C. to adjust to acid. After stirring for 30 minutes, the precipitate was separated by filtration, washed with water, and dried to give the title compound (1.24 g).

1. temperatureunder heating
2. temperaturereflux for 2 hours
3. additionwas added at 0° C.
4. stirringAfter stirring for 30 minutes
5. customthe precipitate was separated by filtration
6. washwashed with water
7. customdried