Hydrochloric Acid → HCID 178516365, compound

HRID 439783Notes

Reaction equation

HRID 439783 reaction equation
[CH2:1]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[N:16][N:17]3[C:22]([OH:23])=[C:21](C(O)=O)[CH:20]=[N:19][C:18]=23)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1C=CC=CC=1.Cl>>[CH2:1]([C:8]1[CH:9]=[CH:10][C:11]([C:14]2[CH:15]=[N:16][N:17]3[C:22]([OH:23])=[CH:21][CH:20]=[N:19][C:18]=23)=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 178524698HCID 178524698, compound

Product 1

HCID 178516365HCID 178516365, compoundYield 83.2%

Procedure

A mixture of 3-(4-benzylphenyl)-6-carboxy-7-hydroxypyrazolo[1,5-a]pyrimidine (1.24 g) and aniline (11 ml) was stirred at 100° C. to 110° C. for 7 hours, and ice-water was put into the reaction mixture. After adding hydrochloric acid to adjust to acid, the reaction mixture was stirred at 0° C. for 1 hour. The precipitate was separated by filtration, washed with methanol-water (1:3)(50 ml), and dried to give the title compound (0.90 g).

Workup

  1. stirringthe reaction mixture was stirred at 0° C. for 1 hour
  2. customThe precipitate was separated by filtration
  3. washwashed with methanol-water (1:3)(50 ml)
  4. customdried

Sources & evidence

ORD record
ord-5815a9b16b44499f9ebfe871a079e1a8
Source dataset
uspto-grants-1996_05
Patent number
US05516777

Reaction notes

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