Hydrochloric Acid → HCID 53859038, compound

HRID 439789Notes

Reaction equation

HRID 439789 reaction equation
[CH2:1]([C:8]1[CH:21]=[CH:20][C:11]([CH2:12][O:13]C2CCCCO2)=[CH:10][C:9]=1[CH3:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>CO>[CH2:1]([C:8]1[CH:21]=[CH:20][C:11]([CH2:12][OH:13])=[CH:10][C:9]=1[CH3:22])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22408174HCID 22408174, compound

Product 1

HCID 53859038HCID 53859038, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(4-benzyl-3-methylbenzyloxy)tetrahydropyran (2.9 g, 0.01 mol) was dissolved in methanol (50 ml). To the obtained solution was added 10% hydrochloric acid (10 ml), and the mixture was stirred at room temperature for 1 hour. After distilling methanol, saturated aqueous sodium chloride solution was added, and the mixture was extracted with etyl acetate. After washing with saturated aqueous sodium hydrogencarbonate solution, water and saturated aqueous sodium chloride solution, the extract was dried over anhydrous sodium sulfate, and the solvent was distilled away to give the title compound (2.2 g, 0.01 mol).

Workup

  1. distillationAfter distilling methanol, saturated aqueous sodium chloride solution
  2. additionwas added
  3. extractionthe mixture was extracted with etyl acetate
  4. washAfter washing with saturated aqueous sodium hydrogencarbonate solution, water and saturated aqueous sodium chloride solution
  5. dry with materialthe extract was dried over anhydrous sodium sulfate
  6. distillationthe solvent was distilled away

Sources & evidence

ORD record
ord-a637bf10da8f4533ba7e9483e8cda6ea
Source dataset
uspto-grants-1996_05
Patent number
US05516777

Reaction notes

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