反应详情

165 ml of tetrahydrofuran are added to 100 g of 2,4-dichloro-5-fluoroaniline at room temperature. To this solution are added 333 ml of tetrafluoroboric acid (50% strength) with cooling. 57.5 g of sodium nitrite in 117 ml of water are added to the reaction mixture cooled to 5°-10° C. in such a way that the internal temperature is 7°-13° C. After addition is completed, the 0° C. solution is filtered. The residue is washed with tetrahydrofuran and ice-cold water. 121 g of product remain.

1. temperaturewith cooling
2. temperaturecooled to 5°-10° C. in such a way that the internal temperature
3. customis 7°-13° C
4. additionAfter addition
5. filtrationthe 0° C. solution is filtered
6. washThe residue is washed with tetrahydrofuran and ice-cold water