Hydrochloric Acid → HCID 178501833, compound

HRID 440316Notes

Reaction equation

HRID 440316 reaction equation
[ClH:1].[NH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([O:9][CH2:10][C:11]([O:13][C:14](C)(C)C)=[O:12])[CH2:5][CH2:4]1>CO>[ClH:1].[NH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([O:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451370HCID 178451370, compound

Product 1

HCID 178501833HCID 178501833, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrochloric acid gas is piped for an hour over a solution of 59.4 g of tert.butyl (trans-4-aminocyclohexyl)oxyacetate in 500 ml of methanol, cooled in an ice bath, and then the mixture is stirred overnight at ambient temperature. It is evaporated to dryness, the residue is triturated with acetone and the solid is suction filtered and dried.

Workup

  1. temperaturecooled in an ice bath
  2. customIt is evaporated to dryness
  3. customthe residue is triturated with acetone
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-03fe03ea10134538a521ae7fd0c90598
Source dataset
uspto-grants-1996_05
Patent number
US05519036

Reaction notes

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