Methanesulfonic Acid → 5-Phenyl-2-thiazole sulfonamide

Participants

Reaction Steps

To a solution of N-t-butyl-5-phenyl-2-thiazole sulfonamide (0.25 g, 0.84 mmol) in 17 mL of 1,2-dichloroethane was added methanesulfonic acid (0.11 mL, 1.68 mmol). The reaction was heated at reflux for 6.5 h and then concentrated. The product was subjected to flash chromatography (2:1 hexane/ethyl acetate). Recrystallization from ethyl acetate/hexane afforded 0.15 g (0.63 mmol, 63%) of 5-phenyl-2-thiazole sulfonamide (white crystals).

Provenance & Evidence