反应详情

To a solution of N-t-butyl-5-phenyl-2-thiazole sulfonamide (0.25 g, 0.84 mmol) in 17 mL of 1,2-dichloroethane was added methanesulfonic acid (0.11 mL, 1.68 mmol). The reaction was heated at reflux for 6.5 h and then concentrated. The product was subjected to flash chromatography (2:1 hexane/ethyl acetate). Recrystallization from ethyl acetate/hexane afforded 0.15 g (0.63 mmol, 63%) of 5-phenyl-2-thiazole sulfonamide (white crystals).

1. temperatureThe reaction was heated
2. temperatureat reflux for 6.5 h
3. concentrationconcentrated
4. customRecrystallization from ethyl acetate/hexane