反应详情

To a solution of N-CBz-4-hydroxy-L-proline (38.1 mmol) in 250 ml THF was added borane-methyl sulfide (78 mmol) dropwise at room temperature. After the evolution of H2 had ceased, the solution was heated to reflux with mechanical stirring. After 1 hour a white precipitate had formed. Methanol was carefully added, and the resulting solution refluxed for a further 15 minutes. The solution was cooled to room temperature, the solvents evaporated under reduced pressure, and the residual gum coevaporated with 2×100 ml MeOH. The product was obtained as a viscous oil in quantitative yield and identified by NMR.

1. temperaturethe solution was heated
2. temperatureto reflux with mechanical stirring
3. customAfter 1 hour a white precipitate had formed
4. temperaturethe resulting solution refluxed for a further 15 minutes
5. customthe solvents evaporated under reduced pressure
6. customThe product was obtained as a viscous oil in quantitative yield