Hydrogen Bromide → HCID 22406811, compound

Participants

Reaction Steps

7-Benzyloxy-6-methoxy-2-methyl-1-[1-(2-methylthiophenyl) cyclobutyl]-1,2,3,4-tetrahydroisoquinoline (1.7 g) was heated under reflux for 2 hours with 48% aqueous hydrobromic acid (15 ml) and glacial acetic acid (15 ml). The solvents were removed by evaporation in vacuo and the residue dried by azeotropic distillation with propan-2-ol. The residue was then dissolved in propan-2-ol, decolourised with charcoal and the solvent evaporated to yield 6,7-dihydroxy-2-methyl-1-[1-(2-methylthiophenyl )cyclobutyl]-1,2,3,4-tetrahydroisoquinoline hydrobromide (1.1 g).

Provenance & Evidence