Hydrochloric Acid → Aminocaproic acid hydrochloride
Reaction equation
[C:1]1(=[O:8])[NH:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:9].[OH2:10]>>[ClH:9].[NH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:1]([OH:8])=[O:10]Participants
4
Procedure
ε-Caprolactam (750.00 g, 6.63 mol), water (1500 mL), and concentrated HCl (675 mL, 36-38%) are combined in a 5000 mL three-necked round bottomed flask fitted with a mechanical stirrer and condenser. The mixture is heated for 4 h at reflux, cooled to room temperature, and concentrated by rotary evaporation at 50° C. (water aspirator vacuum) to give 1 as a white solid. The absence of ε-caprolactam by TLC (Rf =0.21, THF) indicates the reaction is complete.
Workup
- customfitted with a mechanical stirrer and condenser
- temperatureThe mixture is heated for 4 h
- temperatureat reflux
- concentrationconcentrated by rotary evaporation at 50° C. (water aspirator vacuum)
Sources & evidence
- ORD record
- ord-c2fc306c784b4fdc90d964b63133d26b
- Source dataset
- uspto-grants-1996_05
- Patent number
- US05520835
Reaction notes
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