Sodium Iodide → Tert-butyl 2-iodoacetate

HRID 440632ノート

反応式

HRID 440632 の反応式
Cl[CH2:2][C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4].[I-:10].[Na+]>CC(C)=O>[I:10][CH2:2][C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 66052tert-Butyl chloroacetate

生成物 1

HCID 11021060Tert-butyl 2-iodoacetate収率 77.8%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of t-butyl chloroacetate (20 g) and sodium iodide (25 g) is stirred in acetone (200 ml) for twenty hours. The acetone is removed by distillation under reduced pressure. The residue is partitioned between diethyl ether (100 ml) and water (50 ml). The ether layer is washed with water, 5% sodium thiosulfate solution, and water. The organic layer is dried over sodium sulfate, and evaporated under reduced pressure. There is obtained 25 grams of t-butyl iodoacetate. NMR: 63.5, 1.38.

後処理

  1. customThe acetone is removed by distillation under reduced pressure
  2. customThe residue is partitioned between diethyl ether (100 ml) and water (50 ml)
  3. washThe ether layer is washed with water, 5% sodium thiosulfate solution, and water
  4. dry with materialThe organic layer is dried over sodium sulfate
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-3fe4f992b9eb42fb843d2e30f01bb3f4
出典データセット
uspto-grants-1996_05
特許番号
US05521103

反応ノート

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