HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dihydro-2,2-dimethyl-7-nitrobenzofuran-3-one → 7-Amino-2,3-dihydro-2,2-dimethylbenzofuran-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dihydro-2,2-dimethyl-7-nitrobenzofuran-3-one | HCID 22404725 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-Amino-2,3-dihydro-2,2-dimethylbenzofuran-3-one | HCID 22404746 | 68.6% |
Reaction Steps
By the method of Example 1, Step E, 20.0 g (0.097 mole) of 2,3-dihydro-2,2-dimethyl-7-nitrobenzofuran-3-one and 27.0 g (0.483 mole) of powdered iron were reacted in 85 mL of glacial acetic acid and 15 mL of water, yielding 11.79 g of 7-amino-2,3-dihydro-2,2-dimethylbenzofuran-3-one, m.p. 80°-84° C. The NMR and IR spectra of this product were consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05521147 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-942908365e9d4565bffb41e59b9b3348 |
| Source note | uspto-grants-1996_05 |