反应详情

By the method of Example 1, Step E, 20.0 g (0.097 mole) of 2,3-dihydro-2,2-dimethyl-7-nitrobenzofuran-3-one and 27.0 g (0.483 mole) of powdered iron were reacted in 85 mL of glacial acetic acid and 15 mL of water, yielding 11.79 g of 7-amino-2,3-dihydro-2,2-dimethylbenzofuran-3-one, m.p. 80°-84° C. The NMR and IR spectra of this product were consistent with the proposed structure.