Diphosgene → HCID 22404796, compound

HRID 440697Notes

Reaction equation

HRID 440697 reaction equation
[NH2:1][C:2]1[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH:8]=[CH:7][C:6]=2[C:5]([Cl:14])=[CH:4][C:3]=1[F:15].Cl[C:17](OC(Cl)(Cl)Cl)=[O:18]>C1(C)C=CC=CC=1>[Cl:14][C:5]1[C:6]2[CH:7]=[CH:8][C:9]([CH3:13])([CH3:12])[O:10][C:11]=2[C:2]([N:1]=[C:17]=[O:18])=[C:3]([F:15])[CH:4]=1

Participants

4

Reactant 2

HCID 10426DiphosgeneHCID 22404752HCID 22404752, compound

Product 1

HCID 22404796HCID 22404796, compoundYield 110.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

By the method of Example 1, Step F, 1.3 grams (0.005 mole) of 8-amino-5-chloro-2,2-dimethyl-7-fluoro-2H-1-benzopyran and 1.1 grams (0.005 mole) of trichloromethyl chloroformate were reacted in 50 mL of toluene, yielding about 1.4 grams of 5-chloro-2,2-dimethyl-7-fluoro-2H-1-benzopyran-8-yl isocyanate. The product was taken to the next step without further characterization.

Sources & evidence

ORD record
ord-07a903836873440faa3979b54a426914
Source dataset
uspto-grants-1996_05
Patent number
US05521147

Reaction notes

Loading…