Diphosgene → HCID 22404735, compound

HRID 440700Notes

Reaction equation

HRID 440700 reaction equation
[NH2:1][C:2]1[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][CH2:7][C:6]=2[C:5]([Cl:14])=[CH:4][C:3]=1[F:15].Cl[C:17](OC(Cl)(Cl)Cl)=[O:18]>C1(C)C=CC=CC=1>[Cl:14][C:5]1[C:6]2[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[O:10][C:11]=2[C:2]([N:1]=[C:17]=[O:18])=[C:3]([F:15])[CH:4]=1

Participants

4

Reactant 2

HCID 10426DiphosgeneHCID 22404747HCID 22404747, compound

Product 1

HCID 22404735HCID 22404735, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

By the method of Example 1, Step F, 3.6 grams (0.016 mole) of 8-amino-5-chloro-3,4-dihydro-2,2-dimethyl-7-fluoro-2H-1-benzopyran and 3.1 grams (0.016 mole) of trichloromethyl chloroformate were reacted in 100 mL of toluene, yielding about 4.0 grams of 5-chloro-3,4-dihydro-2,2-dimethyl-7-fluoro-2H-1-benzopyran-8-yl isocyanate. The product was taken to the next step without further characterization.

Sources & evidence

ORD record
ord-e80d0106ee55478a8af06648c8ab39ff
Source dataset
uspto-grants-1996_05
Patent number
US05521147

Reaction notes

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