反应详情

To a solution of 1.0 g of 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine in 50 ml of dry methylene chloride, under nitrogen, and 7.0 ml of triethylamine is added 1.43 g of 6-chloro-pyridine-3-carbonyl chloride. The reaction mixture is stirred at room temperature for 16 hours and poured into 100 ml of water. The organic layer is separated, washed with 2% HCl, water, saturated NaHCO3, and dried (Na2SO4). The solvent is evaporated An vacuo to give a residue which is columned on silica gel by elution with 7:1 to 1:1 ethyl acetate:hexane to give 1.76 g of the desired product as a yellowish crystalline solid. M+H=324.

1. customThe organic layer is separated
2. washwashed with 2% HCl, water, saturated NaHCO3
3. dry with materialdried (Na2SO4)
4. customThe solvent is evaporated An vacuo
5. customto give a residue which
6. washis columned on silica gel by elution with 7:1 to 1:1 ethyl acetate