反应详情

To a suspension of 3.07 gm (81 mMol) lithium aluminum hydride in 115 mL diethyl ether at 0° C. were added dropwise a solution of 7.0 gm (45 mMol) 3-fluorophenylacetic acid in 26 mL tetrahydrofuran dropwise. The reaction was allowed to warm to ambient and then stirred 18 hours. The reaction mixture was quenched by the addition of 3.0 mL 2N NaOH dropwise with cooling. To this mixture was then added 9.0 mL water and the resulting suspension stirred for 1 hour at ambient. The suspension was filtered and the filter cake rinsed well with diethyl ether, The filtrate was concentrated under reduced pressure to give 6.26 gm (100%) of the title compound as a clear oil. The product was used without further purification.

1. temperatureto warm to ambient and
2. customThe reaction mixture was quenched by the addition of 3.0 mL 2N NaOH dropwise
3. temperaturewith cooling
4. additionTo this mixture was then added 9.0 mL water
5. stirringthe resulting suspension stirred for 1 hour at ambient
6. filtrationThe suspension was filtered
7. washthe filter cake rinsed well with diethyl ether
8. concentrationThe filtrate was concentrated under reduced pressure