反应详情

温度

50 °C

To a solution of 2.43 g of Compound [76], which had been obtained in Referential Example 6, in 20 ml of methanol, 3.8 ml of an 8% aqueous solution of sodium hydroxide were added, followed by stirring at 50° C. for 20 hours. The reaction mixture was concentrated under reduced pressure. The residue so obtained was extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate and then filtered. The filtrate was concentrated under reduced pressure, The residue was purified by subjecting same to chromatography on a silica gel column using gradient elution with hexane-ethyl acetate, whereby 1.04 g of the title compound were obtained (yield: 70%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customThe residue so obtained
3. extractionwas extracted with ethyl acetate
4. washThe extract was washed with water
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. concentrationThe filtrate was concentrated under reduced pressure
8. customThe residue was purified
9. washelution with hexane-ethyl acetate