Sodium Hydroxide → HCID 22861437, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2.43 g of Compound [76], which had been obtained in Referential Example 6, in 20 ml of methanol, 3.8 ml of an 8% aqueous solution of sodium hydroxide were added, followed by stirring at 50° C. for 20 hours. The reaction mixture was concentrated under reduced pressure. The residue so obtained was extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate and then filtered. The filtrate was concentrated under reduced pressure, The residue was purified by subjecting same to chromatography on a silica gel column using gradient elution with hexane-ethyl acetate, whereby 1.04 g of the title compound were obtained (yield: 70%).

Provenance & Evidence