Hydrogen Bromide → HCID 14621582, compound

HRID 441008Notes

Reaction equation

HRID 441008 reaction equation
Br.Br.[N+:3]([C:6]1[N:7]([CH2:11][CH:12]([OH:22])[CH2:13][NH:14][C:15]([CH3:21])([CH3:20])[C:16]([Br:19])([CH3:18])[CH3:17])[CH:8]=[CH:9][N:10]=1)([O-:5])=[O:4]>>[N+:3]([C:6]1[N:7]([CH2:11][CH:12]([OH:22])[CH2:13][NH:14][C:15]([CH3:21])([CH3:20])[C:16]([Br:19])([CH3:18])[CH3:17])[CH:8]=[CH:9][N:10]=1)([O-:5])=[O:4]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 14621583HCID 14621583, compound

Product 1

HCID 14621582HCID 14621582, compoundYield 56%

Procedure

In a manner analogous to that described in Example 2(b) there was obtained following condensation of 1-(2-nitro-1-imidazolyl)-3-(2,2,3,3-tetramethyl-1-aziridino)-2-propanol with aqueous hydrobromic acid, 1-(2-nitro-1-imidazolyl)-3-(2-bromo-2,3-dimethyl-3-butylamino)-2-propanol hydrobromide as pale yellow prisms, m.p. 163°-164° C. (dec.) after evaporation to low volume and recrystallisation from aqueous acetone; yield 56%.

Workup

  1. customwas obtained
  2. customafter evaporation
  3. customto low volume and recrystallisation from aqueous acetone

Sources & evidence

ORD record
ord-9eb66b1c4c784027abd82c43ad27032a
Source dataset
uspto-grants-1996_05
Patent number
US05521203

Reaction notes

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