HCID 22405712, compound → HCID 22405713, compound

HRID 441088Notes

Reaction equation

HRID 441088 reaction equation
[CH3:1][O:2][C:3]1[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([C:27]5[C:28](=[O:33])[C:29](=[O:32])[C:30]=5[NH2:31])[CH:25]=4)[N:20]([Si](C(C)C)(C(C)C)C(C)C)[CH:19]=3)[CH2:11][CH2:10]2)=[N:5][CH:6]=[N:7][CH:8]=1>C(#N)C.C([O-])(O)=O.[Na+]>[CH3:1][O:2][C:3]1[C:4]([N:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([C:27]5[C:28](=[O:33])[C:29](=[O:32])[C:30]=5[NH2:31])[CH:25]=4)[NH:20][CH:19]=3)[CH2:13][CH2:14]2)=[N:5][CH:6]=[N:7][CH:8]=1

Participants

4

Reactant 1

HCID 22405712HCID 22405712, compound

Product 1

HCID 22405713HCID 22405713, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 516892Sodium BicarbonateSolvent

Procedure

To a solution of 3-[3-[4-(5-methoxy-4-pyrimidyl)-1-piperazinyl]propyl]-5-(1,2-dioxo-4-amino-3-cyclobuten-3-yl)-1-triisopropylsilylindole (0.280 g, 0.465 mmol) in 10 mL of acetonitrile was added 48% HF (34 μL, 0.94 mmol) and the mixture was stirred at room temperature for 2 h. The resulting suspension was filtered and the residue was washed with acetonitrile and ether, and then it was air-dried to give a pale yellow solid. The solid was suspended in saturated aqueous NaHCO3 with vigorous stirring and the suspension was then filtered and the residue was washed with water, a little ethanol and finally with ether. This material was dried in vacuo to give the title compound (0.194 g, 94%) as a yellow solid. Crystallization from ethanol afforded the analytical sample (0.141 g, 68%) as a beige solid, mp 233° C. (dec): IR (KBr) 3330, 3195, 1772, 1700, 1660, 1577 cm-1 ; 1H NMR (DMSO-d6, 200 MHz) d 11.15 (br s, 1H), 8.93 (br s, 1H), 8.83 (br s, 1H), 8.27 (s, 1H), 8.22 (s, 1H), 8.01 (s, 1H), 7.83 (d, J=8.5 Hz, 1H), 7.44 (d, J=8.5 Hz, 1H), 7.24 (s, 1H), 3.81 (s, 3H), 3.67 (br s, 4H), 2.81-2.73 (m, 2H), 2.49-2.35 (m, 6H), 1.88-1.81 (m, 2H). Anal. Calcd for C24H26N6O3. 0.5 H2O. 0.25 C2H6O: C, 63.06; H, 6.12; N, 18.08. Found: C, 63.32; H, 5.83; N, 17.73.

Workup

  1. filtrationThe resulting suspension was filtered
  2. washthe residue was washed with acetonitrile and ether
  3. customit was air-dried
  4. customto give a pale yellow solid
  5. stirringwith vigorous stirring
  6. filtrationthe suspension was then filtered
  7. washthe residue was washed with water
  8. customThis material was dried in vacuo

Sources & evidence

ORD record
ord-35ba7bb9b181473fb8178fea453a0d05
Source dataset
uspto-grants-1996_05
Patent number
US05521188

Reaction notes

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