反应详情

温度

0 °C

To a solution of 11-dodecen-1-ol (5.5 g, 29.9 mmol) in dichloromethane (70 ml) at 0° C. was added methanesulfonyl chloride (3.55 g, 2.40 ml, 31.0 mmol) followed by triethylamine (4.38 g, 46.0 mmol). After stirring for 10 min at 0° C., the reaction was allowed to warm to 25° C. and stirred for 2 hr. The reaction was poured into water (60 ml), separated and washed with dichloromethane (50 ml). The organic portions were combined, dried (magnesium sulfate), and evaporated to give the 12-methanesulfonyl-1-dodecene as a yellow oil which was used without further purification.

1. temperatureto warm to 25° C.
2. stirringstirred for 2 hr
3. customseparated
4. washwashed with dichloromethane (50 ml)
5. dry with materialdried (magnesium sulfate)
6. customevaporated