Trifluoroacetic acid → HCID 10409050, compound

HRID 441176Notes

Reaction equation

HRID 441176 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C:12]1[C:13](=[O:34])[N:14]([CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])[C:15]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:16][CH:17]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[CH2:1]([O:8][C:9]([NH:11][C:12]1[C:13](=[O:34])[N:14]([CH2:26][C:27]([OH:29])=[O:28])[C:15]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:16][CH:17]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 10095881HCID 10095881, compound

Product 1

HCID 10409050HCID 10409050, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl (3-benzyloxycarbonylamino-2-oxo-6-phenethyl-1,2-dihydro-1-pyridyl)acetate (0.554 g) in dichloromethane (distilled from CaH) was added trifluoroacetic acid (1.50 ml); and the mixture was stirred overnight, evaporated, and dried under vacuum to afford (3-benzyloxycarbonylamino-2-oxo-6-phenethyl-1,2-dihydro-1-pyridyl)acetic acid; MS: m/z=407(M+1).

Workup

  1. customevaporated
  2. customdried under vacuum

Sources & evidence

ORD record
ord-af19cf2e8a6348bebbdccb7637963cb6
Source dataset
uspto-grants-1996_05
Patent number
US05521179

Reaction notes

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