HCID 10324214, compound → HCID 10391723, compound

HRID 441179Notes

Reaction equation

HRID 441179 reaction equation
[O:1]=[C:2]1[C:7]([NH:8][C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:6][CH:5]=[C:4]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:3]1[CH2:24][C:25]([NH:27][CH:28]([CH:35]([CH3:37])[CH3:36])[CH:29]([OH:34])[C:30]([F:33])([F:32])[F:31])=[O:26]>CO.ClCCl>[O:1]=[C:2]1[C:7]([NH:8][C:9](=[O:17])[CH2:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:6][CH:5]=[C:4]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:3]1[CH2:24][C:25]([NH:27][CH:28]([CH:35]([CH3:37])[CH3:36])[C:29](=[O:34])[C:30]([F:32])([F:31])[F:33])=[O:26]

Participants

3

Reactant 1

HCID 10324214HCID 10324214, compound

Product 1

HCID 10391723HCID 10391723, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Using a similar procedure to that described in Example 1, using methanol:dichloromethane (1:99) as the chromatography solvent, 2-(2-oxo-6-phenyl-3-phenylacetylamino-1,2-dihydro-1-pyridyl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide was oxidized to afford the title product; HPLC: tR =6.92, FR=2.0, column A, water:acetonitrile (55.45); MS: m/z=514(M+1).

Sources & evidence

ORD record
ord-af48b3bf5e644e9599504687c9a4198c
Source dataset
uspto-grants-1996_05
Patent number
US05521179

Reaction notes

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