反应详情

To a suspension of 3-methylisonicotinic acid (0.676 g) in toluene was added thionyl chloride (0.5 mL), and the reaction mixture was heated under reflux 70 min. The resulting solution was decanted from a gummy residue on the bottom of the reaction flask, evaporated and further dried under high vacuum to afford 3-methylisonicotinoyl chloride hydrochloride which was used for the acylation without further purification.

1. temperaturethe reaction mixture was heated
2. temperatureunder reflux 70 min
3. customThe resulting solution was decanted from a gummy residue on the bottom of the reaction flask
4. customevaporated
5. customfurther dried under high vacuum