Thionyl Chloride → 3-Methylpyridine-4-carbonyl chloride--hydrogen chloride (1/1)

Participants

Reaction Steps

To a suspension of 3-methylisonicotinic acid (0.676 g) in toluene was added thionyl chloride (0.5 mL), and the reaction mixture was heated under reflux 70 min. The resulting solution was decanted from a gummy residue on the bottom of the reaction flask, evaporated and further dried under high vacuum to afford 3-methylisonicotinoyl chloride hydrochloride which was used for the acylation without further purification.

Provenance & Evidence