HCID 10371178, compound → HCID 22405541, compound

HRID 441210Notes

Reaction equation

HRID 441210 reaction equation
C(OC([NH:11][C:12]1[C:13](=[O:42])[N:14]([CH2:28][C:29]([NH:31][CH:32]([CH:39]([CH3:41])[CH3:40])[C:33](=[O:38])[C:34]([F:37])([F:36])[F:35])=[O:30])[C:15]([C:18]2[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[C:20]([O:26][CH3:27])[CH:19]=2)=[CH:16][CH:17]=1)=O)C1C=CC=CC=1.[H][H]>>[NH2:11][C:12]1[C:13](=[O:42])[N:14]([CH2:28][C:29]([NH:31][CH:32]([CH:39]([CH3:40])[CH3:41])[C:33](=[O:38])[C:34]([F:36])([F:35])[F:37])=[O:30])[C:15]([C:18]2[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[C:20]([O:26][CH3:27])[CH:19]=2)=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 10371178HCID 10371178, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22405541HCID 22405541, compound

Procedure

2-[3-Benzyloxycarbonylamino-6-(3,5-dimethoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide was subjected to the conditions described in Example 159, except with shaking under a 2.7 bar hydrogen atmosphere, to give the title compound. Chromatography solvent: Dichloromethane:methanol (98:2, 95:5); TLC: Rf =0.35, dichloromethane:methanol (95:5); MS: m/z=456(M+1).

Sources & evidence

ORD record
ord-e9ba9d4c44e44e7389e7d80154a146bb
Source dataset
uspto-grants-1996_05
Patent number
US05521179

Reaction notes

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