HRID441255

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：CC(=O)OCCN1C(=O)CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccc(C)cc3)cc2)c2ccccc21

HCID22405046

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3CCC(=O)N(CCO)c4ccccc43)cc2)cc1

HCID22405269

未命名化合物

收率 103.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

A mixture of 1-(2-acetoxyethyl)-5-{4-[2-(4-methylphenyl)benzoylamino]benzoyl}-1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one (450 mg) and potassium carbonate (117 mg) in methanol (15 ml) was stirred at ambient temperature for 3 hours. The mixture was diluted with chloroform and the solution was washed with water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give 1-(2-hydroxyethyl)-5-{4-[2-(4-methylphenyl)benzoylamino]benzoyl}-1,3,4,5-tetrahydro -1,5-benzodiazepin-2(2H)-one (430 mg).

WORKUP

后处理

washthe solution was washed with water and brine
dry with materialdried over magnesium sulfate
customThe solvent was evaporated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-86b64a43efb0438ca40560b352bc21d1
来源数据集: uspto-grants-1996_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05521170
来源说明: uspto-grants-1996_05

反应 SMILES

C([O:4][CH2:5][CH2:6][N:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[N:11]([C:18](=[O:41])[C:19]2[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:40])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]3[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][CH:34]=3)=[CH:21][CH:20]=2)[CH2:10][CH2:9][C:8]1=[O:42])(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.C(Cl)(Cl)Cl>[OH:4][CH2:5][CH2:6][N:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[N:11]([C:18](=[O:41])[C:19]2[CH:20]=[CH:21][C:22]([NH:25][C:26](=[O:40])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]3[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][CH:34]=3)=[CH:23][CH:24]=2)[CH2:10][CH2:9][C:8]1=[O:42]