Methyl iodide → HCID 69948022, compound

HRID 441263Notes

Reaction equation

HRID 441263 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:46]=[CH:45][CH:44]=[CH:43][C:9]=2[C:10]([NH:12][C:13]2[CH:42]=[CH:41][C:16]([C:17]([N:19]3[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[N:23]([CH2:30][C:31]([N:33]4[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]4)=[O:32])[C:22](=[O:40])[CH2:21][CH2:20]3)=[O:18])=[CH:15][CH:14]=2)=[O:11])=[CH:4][CH:3]=1.[CH3:47][I:48]>ClCCl>[I-:48].[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:46]=[CH:45][CH:44]=[CH:43][C:9]=2[C:10]([NH:12][C:13]2[CH:42]=[CH:41][C:16]([C:17]([N:19]3[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[N:23]([CH2:30][C:31]([N:33]4[CH2:34][CH2:35][N+:36]([CH3:47])([CH3:39])[CH2:37][CH2:38]4)=[O:32])[C:22](=[O:40])[CH2:21][CH2:20]3)=[O:18])=[CH:15][CH:14]=2)=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 9873768HCID 9873768, compound

Product 1

HCID 69948022HCID 69948022, compoundYield 87.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 5-{4-[2-(4-methylphenyl)benzoylamino]benzoyl}-1-(4-methyl-1-piperazinylcarbonyl)methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one (110 mg) and methyl iodide (76.1 mg) in dichloromethane (10 ml) was stirred at ambient temperature overnight and a precipitate was filtered to give 4-{5-{4-[2-(4-methylphenyl)benzoylamino]benzoyl}-2-oxo-1,3,4 ,5-tetrahydro-2H-1,5-benzodiazepin-1-yl) acetyl-1,1-dimethylpiperazinium iodide (118 mg).

Workup

  1. filtrationa precipitate was filtered

Sources & evidence

ORD record
ord-a252d20c895748b4bbfb7a4690a24ec7
Source dataset
uspto-grants-1996_05
Patent number
US05521170

Reaction notes

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