反应详情

Following a procedure similar to that described in Example 1 but using 2.3 g. sodium in 300 ml. dry acetone, 16.4 g. heptanamidine hydrochloride, and 21.9 g. 4-(trifluoromethoxy)phenyl isothiocyanate [b.p. 88° C./7 mm.; prepared from 4-(trifluoromethoxy)aniline] in 120 ml. dry acetone there was obtained 1-[4-(trifluoromethoxy)phenyl]-3-(heptanimidoyl)-2-thiourea, m.p. 90°-91° C. (from benzene-n-pentane); hydrochloride (25.3 g.), m.p. 171°-172° C. (from acetonitrile).