Acetone → HCID 178444029, compound

HRID 441337Notes

Reaction equation

HRID 441337 reaction equation
[Na].CC(C)=O.Cl.[C:7]([NH2:15])(=[NH:14])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[F:16][C:17]([F:29])([F:28])[O:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]=[C:26]=[S:27])=[CH:21][CH:20]=1>C1C=CC=CC=1.CCCCC>[F:16][C:17]([F:28])([F:29])[O:18][C:19]1[CH:20]=[CH:21][C:22]([NH:25][C:26]([NH:14][C:7](=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:27])=[CH:23][CH:24]=1

Participants

6

Reactant 4

HCID 180Acetone2×HCID 27773384-(Trifluoromethoxy)phenyl isothiocyanateHCID 5360545SodiumHCID 14144282Heptanimidamide hydrochloride

Product 1

HCID 178444029HCID 178444029, compound

Reagents, catalysts & solvents 1

HCID 19707280Benzene n-pentaneSolvent

Procedure

Following a procedure similar to that described in Example 1 but using 2.3 g. sodium in 300 ml. dry acetone, 16.4 g. heptanamidine hydrochloride, and 21.9 g. 4-(trifluoromethoxy)phenyl isothiocyanate [b.p. 88° C./7 mm.; prepared from 4-(trifluoromethoxy)aniline] in 120 ml. dry acetone there was obtained 1-[4-(trifluoromethoxy)phenyl]-3-(heptanimidoyl)-2-thiourea, m.p. 90°-91° C. (from benzene-n-pentane); hydrochloride (25.3 g.), m.p. 171°-172° C. (from acetonitrile).

Sources & evidence

ORD record
ord-18a016a055ae48bdb250430db70de792
Source dataset
uspto-grants-1977_08
Patent number
US04039575

Reaction notes

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