HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Naphthalenecarbonyl chloride → N-(1-Cyclohexyl-3-pyrrolidinyl)-N-methyl-1-naphthalenecarboxamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Naphthalenecarbonyl chloride | HCID 70146 | — |
| Reactant | 1-Cyclohexyl-N-methylpyrrolidin-3-amine | HCID 12895717 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | N-(1-Cyclohexyl-3-pyrrolidinyl)-N-methyl-1-naphthalenecarboxamide Hydrochloride | HCID 20355406 | — |
Reaction Steps
To 18.8 gm. (0.11 mole) of 1-cylohexyl-3-methylaminopyrrolidine in dry benzene was added dropwise with stirring 19.0 gm. (0.10 mole) of 1-naphthalenecarbonyl chloride in dry benzene. The crystalline product which separated was collected and recrystallized from benzene to give 27.5 gm. (74%) of product which melted at 219°-221° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04039678 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-25886b8acd6b4d5fa6243a1cf685844b |
| Source note | uspto-grants-1977_08 |