Ethyl Acetate → HCID 21418619, compound

HRID 441464Notes

Reaction equation

HRID 441464 reaction equation
[CH:1]1([C:4]2[S:8][C:7]([N:9]=[C:10]=[O:11])=[N:6][N:5]=2)[CH2:3][CH2:2]1.[CH3:12][C:13]([NH2:17])(C)[CH:14]=[O:15].[C:18](OCC)(=O)C>>[CH3:18][N:17]([CH:13]([CH3:12])[CH:14]=[O:15])[C:10]([NH:9][C:7]1[S:8][C:4]([CH:1]2[CH2:3][CH2:2]2)=[N:5][N:6]=1)=[O:11]

Participants

4

Reactant 3

HCID 8857Ethyl AcetateHCID 21903907HCID 21903907, compoundHCID 539755145-Cyclopropyl-1,3,4-thiadiazol-2-yl isocyanate

Product 1

HCID 21418619HCID 21418619, compound

Procedure

A mixture of 5-cyclopropyl-1,3,4-thiadiazol-2-yl isocyanate dimer (7 grams), the dimethyl acetal of 2-methyl-aminopropionaldehyde (6 grams) and ethyl acetate (50 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and reflux condenser. The reaction mixture is heated at reflux for a period of about 2 hours. After this time the mixture is stripped of solvent under reduced pressure to yield the desired product the dimethyl acetal of 2-[1-methyl-3-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)ureido]-propionaldehyde.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture is heated
  4. temperatureat reflux for a period of about 2 hours

Sources & evidence

ORD record
ord-30b6829d9d53454c9712b6867a3783f8
Source dataset
uspto-grants-1977_08
Patent number
US04040812

Reaction notes

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