Methanol → HCID 21419079, compound

HRID 441501Notes

Reaction equation

HRID 441501 reaction equation
[Na].Cl[C:3]1[C:4]([C:11]([O:13][CH3:14])=[O:12])=[N:5][C:6]([CH3:10])=[C:7]([CH3:9])[N:8]=1.[CH3:15][OH:16]>>[CH3:15][O:16][C:3]1[C:4]([C:11]([O:13][CH3:14])=[O:12])=[N:5][C:6]([CH3:10])=[C:7]([CH3:9])[N:8]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 2141902557796-66-4

Product 1

HCID 21419079HCID 21419079, compound

Procedure

To 20 ml. of a solution of 0.1 g. metallic sodium in methanol was added 0.3 g. of methyl 3-chloro-5,6-dimethylpyrazine-2-carboxylate and the mixture was refluxed for one hour. The methanol was distilled off from the reaction mixture and the residue obtained was added to 20 ml. of water and the mixture was extracted three times each time with 20 ml. of dichloromethane. The extracts were combined, dried over anhydrous magnesium sulfate, and then the dichloromethane was distilled off to provide 0.2 g of methyl 3-methoxy-5,6-dimethylpyrazine-2-carboxylate. The yellow prism crystals obtained by recrystallizing from n-hexane melted at 80°-81° C.

Workup

  1. distillationThe methanol was distilled off from the reaction mixture
  2. customthe residue obtained
  3. additionwas added to 20 ml
  4. extractionof water and the mixture was extracted three times each time with 20 ml
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationthe dichloromethane was distilled off

Sources & evidence

ORD record
ord-0433749e8bf042ddbf6a78bd3ce7f1a2
Source dataset
uspto-grants-1977_08
Patent number
US04041032

Reaction notes

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