Potassium Hydroxide → HCID 21419183, compound

HRID 441504Notes

Reaction equation

HRID 441504 reaction equation
Cl[CH:2]([C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[CH2:6][CH2:7][O:8][NH:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:3].[OH-].[K+]>C(O)C>[C:10]([N:9]1[O:8][CH2:7][CH2:6][C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=2[CH:2]1[CH3:3])([O:12][CH2:13][CH3:14])=[O:11]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 21419168HCID 21419168, compound

Product 1

HCID 21419183HCID 21419183, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of 18.5 g. of O-[o-(1-chloroethyl)-phenethyl]-N-carbethoxyhydroxylamine in 130 ml. of ethanol was treated with 3.85 g. of potassium hydroxide in 55 ml. of ethanol according to the procedure described in Example 1. The end product was recovered by distillation collecting the fraction boiling at 115° C./0.1 mm Hg. The fraction boiling at 100° C./0.2 mm Hg which contained the by-product O-(o-vinylphenethyl)-N-carbethoxyhydroxylamine was discarded. There was thus obtained 7.8 g. of 2-carbethoxy-1-methyl-1,2,4,5-tetrahydro-3,2-benzoxazepine.

Workup

  1. distillationThe end product was recovered by distillation
  2. customcollecting the fraction boiling at 115° C./0.1 mm Hg

Sources & evidence

ORD record
ord-a13e7e74af5d433889fff9273624e748
Source dataset
uspto-grants-1977_08
Patent number
US04041048

Reaction notes

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