Potassium Hydroxide → HCID 21419183, compound

Participants

Reaction Steps

A solution of 18.5 g. of O-[o-(1-chloroethyl)-phenethyl]-N-carbethoxyhydroxylamine in 130 ml. of ethanol was treated with 3.85 g. of potassium hydroxide in 55 ml. of ethanol according to the procedure described in Example 1. The end product was recovered by distillation collecting the fraction boiling at 115° C./0.1 mm Hg. The fraction boiling at 100° C./0.2 mm Hg which contained the by-product O-(o-vinylphenethyl)-N-carbethoxyhydroxylamine was discarded. There was thus obtained 7.8 g. of 2-carbethoxy-1-methyl-1,2,4,5-tetrahydro-3,2-benzoxazepine.

Provenance & Evidence