反应详情

温度

45 °C

Trans ethyl 3-bromocinnamate (8.4 g), ethylamine (6.7 g), methanol (18 ml) and 4A molecular sieves (1 g) were combined and heated at reflux for 1/2 hour. The mixture was cooled to about 45° C. and sodium methylate (0.6 g) added. The mixture was then heated at reflux 11/2 hour and then cooled. It was acidified with concentrated hydrochloric acid (12 ml). The sieves were removed by filtration. Ice water was added to the filtrate to precipitate trans 3-bromo-N-ethylcinnamamide, m.p. 89°-90° C. (after recrystallization from ethanol/water).

1. temperatureheated
2. temperatureat reflux for 1/2 hour
3. temperatureThe mixture was then heated
4. temperatureat reflux 11/2 hour
5. temperaturecooled
6. customThe sieves were removed by filtration
7. additionIce water was added to the filtrate
8. customto precipitate
9. customtrans 3-bromo-N-ethylcinnamamide, m.p. 89°-90° C. (after recrystallization from ethanol/water)