Hydrochloric Acid → 1-Butanone, 1,1'-(9H-fluorene-2,7-diyl)bis(4-(1-piperidinyl)-, dihydrochloride

HRID 441649Notes

Reaction equation

HRID 441649 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][C:10]([C:12]2[CH:24]=[CH:23][C:22]3[C:21]4[C:16](=[CH:17][C:18]([C:25](=[O:35])[CH2:26][CH2:27][CH2:28][N:29]5[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]5)=[CH:19][CH:20]=4)[CH2:15][C:14]=3[CH:13]=2)=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:36]>>[ClH:36].[ClH:36].[N:1]1([CH2:7][CH2:8][CH2:9][C:10]([C:12]2[CH:24]=[CH:23][C:22]3[C:21]4[C:16](=[CH:17][C:18]([C:25](=[O:35])[CH2:26][CH2:27][CH2:28][N:29]5[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]5)=[CH:19][CH:20]=4)[CH2:15][C:14]=3[CH:13]=2)=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 1602411,1'-(9H-Fluorene-2,7-diyl)bis(4-(1-piperidinyl)-1-butanone)

Product 1

HCID 1696471-Butanone, 1,1'-(9H-fluorene-2,7-diyl)bis(4-(1-piperidinyl)-, dihydrochloride

Procedure

By the procedure of Example 28, 2,7-bis(4-piperidinobutyryl)fluorene is prepared and dissolved in a chloroformbutanone mixture. The resulting solution is acidified with ethereal HCl, and the solid precipitate recrystallized three times from methanol-butanone to give 2,7-bis(4-piperidinobutyryl)fluorene dihydrochloride, M.P. 286°-288° C.

Workup

  1. dissolutiondissolved in a chloroformbutanone mixture
  2. customthe solid precipitate recrystallized three times from methanol-butanone

Sources & evidence

ORD record
ord-258f02c34b9646b7b7bd0b59bd8a55e5
Source dataset
uspto-grants-1977_08
Patent number
US04041165

Reaction notes

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