Cyclohexylamine → 2-[(Cyclohexylcarbamoyl)amino]benzene-1-sulfonyl fluoride

HRID 441699Notes

Reaction equation

HRID 441699 reaction equation
[F:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]=[C:12]=[O:13])(=[O:4])=[O:3].[CH:14]1([NH2:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>C1C=CC=CC=1>[CH:14]1([NH:20][C:12]([NH:11][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:2]([F:1])(=[O:4])=[O:3])=[O:13])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 204669492-Isocyanatobenzene-1-sulfonyl fluoride

Product 1

HCID 214172322-[(Cyclohexylcarbamoyl)amino]benzene-1-sulfonyl fluoride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a stirred solution of 2-fluorosulphonyl phenyl isocyanate (804 g, 4 moles) in benzene (4 l), cyclohexylamine (457 ml, 4 moles) was added dropwise, whilst the temperature was kept at 60°. The mixture was left standing overnight at room temperature, whereupon the product was collected, washed with benzene (4 l) and dried. Yield : 1070-1090 g (89-90 %), melting point: 177° C.

Workup

  1. customwas kept at 60°
  2. waitThe mixture was left
  3. customwas collected
  4. washwashed with benzene (4 l)
  5. customdried

Sources & evidence

ORD record
ord-f138a80485414e23bdd961661a9b15e7
Source dataset
uspto-grants-1977_08
Patent number
US04042397

Reaction notes

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