Cyclohexylamine → 2-[(Cyclohexylcarbamoyl)amino]benzene-1-sulfonyl fluoride

Participants

Reaction Steps

To a stirred solution of 2-fluorosulphonyl phenyl isocyanate (804 g, 4 moles) in benzene (4 l), cyclohexylamine (457 ml, 4 moles) was added dropwise, whilst the temperature was kept at 60°. The mixture was left standing overnight at room temperature, whereupon the product was collected, washed with benzene (4 l) and dried. Yield : 1070-1090 g (89-90 %), melting point: 177° C.

Provenance & Evidence