反应详情

1.0 g. of 2-methyl-5-phenethyl-4-oxazolecarbonyl chloride (obtainable by Step D, above) in 15 ml. of carbon disulfide, 2.5 g. of anhydrous aluminum chloride added, and the mixture refluxed for 1 hour. The mixture is then cooled, poured on to ice, and extracted twice with 10 ml. portions of chloroform. The extracts are combined, dried over anhydrous sodium sulfate and evaporated (under vacuum) to obtain a solid residue, which is recyrstallized from ethyl acetate to obtain the title compound, m.p. 174°-176°.

1. temperaturethe mixture refluxed for 1 hour
2. temperatureThe mixture is then cooled
3. additionpoured on to ice
4. extractionextracted twice with 10 ml
5. dry with materialdried over anhydrous sodium sulfate
6. customevaporated (under vacuum)
7. customto obtain a solid residue, which