Ammonium Hydroxide → 2-Amino-6-methoxypyrazine 4-oxide

HRID 441735Notes

Reaction equation

HRID 441735 reaction equation
Cl[C:2]1[CH:7]=[N+:6]([O-:8])[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1.[OH-].[NH4+:12]>>[NH2:12][C:2]1[CH:7]=[N+:6]([O-:8])[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 205289402-Chloro-6-methoxypyrazine 4-oxide

Product 1

HCID 205289822-Amino-6-methoxypyrazine 4-oxide

Procedure

2-Chloro-6-methoxypyrazine 4-oxide is treated with an excess of ammonium hydroxide in an autoclave at 150° C. for 14 hours. The reaction mixture is cooled and evaporated to dryness to give the crude product which may be used in the next step as is.

Workup

  1. temperatureThe reaction mixture is cooled
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-b4ba8aed85694781b34d4c8470541b07
Source dataset
uspto-grants-1977_08
Patent number
US04042586

Reaction notes

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