Sodium Nitrate → HCID 20528962, compound

HRID 441738Notes

Reaction equation

HRID 441738 reaction equation
N[C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:5]=[C:4]([O:14][CH3:15])[N:3]=1.[N+]([O-])([O-])=O.[Na+].OC1C(N2CCOCC2)=NC=C(OC)N=1.P(Cl)(Cl)([Cl:38])=O>>[Cl:38][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:5]=[C:4]([O:14][CH3:15])[N:3]=1

Participants

5

Reactant 4

HCID 24268Sodium NitrateHCID 24813Phosphorus oxychlorideHCID 20528919HCID 20528919, compoundHCID 178493780HCID 178493780, compound

Product 1

HCID 20528962HCID 20528962, compound

Procedure

The 2-amino substituent of Step A product when treated with sodium nitrate as described in Step E of Preparation 81 is converted to the 2-hydroxy group. Treatment of the 2-hydroxy-3-morpholino-6-methoxypyrazine with phosphorus oxychloride by Preparation 13, Step B method, gives 2-chloro-3-morpholino-6-methoxypyrazine.

Workup

  1. customas described in Step E of Preparation 81

Sources & evidence

ORD record
ord-743d1c986dce47c7b582e254ffe841c4
Source dataset
uspto-grants-1977_08
Patent number
US04042586

Reaction notes

Loading…