反应详情

温度

175 °C

A mixture of 2-hydroxy-3-methyl-5-bromopyrazine and phosphorus oxybromide is heated at about 175° C. for several hours with constant stirring. After hydrolysis of the solution on ice the crude product is extracted with ether and distilled. The distillate is refluxed with phosphorus tribromide for several hours and, after cooling, the solution is hydrolyzed on ice and the product extracted with ether, the ether removed in vacuo to give 2,5-dibromo-3-methylpyrazine.

1. extractionis extracted with ether
2. distillationdistilled
3. temperatureThe distillate is refluxed with phosphorus tribromide for several hours
4. temperatureafter cooling
5. extractionthe product extracted with ether
6. customthe ether removed in vacuo