Phosphorus oxychloride → 2-Chloro-3,5-dimorpholinopyrazine

HRID 441749Notes

Reaction equation

N[C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][C:5]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:4][N:3]=1.N([O-])=O.[Na+].P(Cl)(Cl)([Cl:26])=O>>[Cl:26][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][C:5]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:4][N:3]=1

Participants

Reactant 3

HCID 24813Phosphorus oxychloride

HCID 205289312-Amino-3,5-dimorpholinopyrazine

HCID 23668193Sodium Nitrite

Product 1

HCID 205289902-Chloro-3,5-dimorpholinopyrazine

Procedure

This product is obtained by treating the 2-amino-3,5-dimorpholinopyrazine with sodium nitrite by the method described in the preceding procedure, Step C, and then with phosphorus oxychloride by the method described in Preparation 13, Step B.

Workup

customThis product is obtained

Sources & evidence

ORD record: ord-fabb0f34a4a74f719b2f0ccf291e5024
Source dataset: uspto-grants-1977_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04042586

Reaction notes

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