HCID 85848304, compound → HCID 85848305, compound

HRID 441764Notes

Reaction equation

HRID 441764 reaction equation
[CH2:1]([N:3]1[CH2:10][CH:9]2[CH:5]([CH2:6][CH2:7][CH2:8]2)[C:4]1=[CH:11][N+:12]([O-])=O)[CH3:2]>[Ni].CO>[CH2:1]([N:3]1[CH2:10][CH:9]2[CH:5]([CH2:6][CH2:7][CH2:8]2)[CH:4]1[CH2:11][NH2:12])[CH3:2]

Participants

4

Reactant 1

HCID 85848304HCID 85848304, compound

Product 1

HCID 85848305HCID 85848305, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

54 parts of N-ethyl-2-nitromethylene-3-azabicyclo (3,3,0) octane, in solution in 500 parts of anhydrous methanol were reduced in presence of 20 parts of Raney Nickel at 5 kg/m2 pressure. After filtration and washing of the catalyst by methanol, the filtrate was evaporated under vacuo then distilled. There were obtained 30 parts of N-ethyl-2-aminomethyl-3-azabicyclo (3,3,0) octane, B.P./0.25-0.30 mmHg : 88°-90° C. This reduction can be easily carried out with lithium aluminium hydride too.

Workup

  1. filtrationAfter filtration
  2. washwashing of the catalyst by methanol
  3. customthe filtrate was evaporated under vacuo
  4. distillationthen distilled

Sources & evidence

ORD record
ord-28414dff23ce411d9630523937206d35
Source dataset
uspto-grants-1977_08
Patent number
US04042598

Reaction notes

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