HCID 85848304, compound → HCID 85848305, compound

Participants

Reaction Steps

54 parts of N-ethyl-2-nitromethylene-3-azabicyclo (3,3,0) octane, in solution in 500 parts of anhydrous methanol were reduced in presence of 20 parts of Raney Nickel at 5 kg/m2 pressure. After filtration and washing of the catalyst by methanol, the filtrate was evaporated under vacuo then distilled. There were obtained 30 parts of N-ethyl-2-aminomethyl-3-azabicyclo (3,3,0) octane, B.P./0.25-0.30 mmHg : 88°-90° C. This reduction can be easily carried out with lithium aluminium hydride too.

Provenance & Evidence